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PEA (Palmitoylethanolamide) (Small Dog (300mg), Medium Dog (600mg), Large-XL Dog (1000mg)
300mg
600mg
1000mg
PEA (Palmitoylethanolamide) (Small Dog (300mg), Medium Dog (600mg), Large-XL Dog (1000mg)
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Features Plus

PEA

PEA is a naturally occurring fatty acid amide which affects endocannabinoid signalling. PEA achieves its analgesic effects via indirect activation of the cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptors; as well as indirect activation of PPAR-alpha, and several other receptors.

PEA has been explored since 1957 and has a clear analgesic and anti-inflammatory efficacy, and virtually no side effects. Meanwhile within the context of clinical trials 5000 patients have been using PEA, and its efficacy and safety has been documented in more than 500 scientific papers.

PEA is referred to as a natural painkiller and anti-inflammatory compound. PEA is produced in our cells and found in some foods.

It is proven to be effective and safe in many human clinical trials in more than 5000 patients and can be combined with any other compound, allowing it to be used as part of a multi-faceted treatment plan for pain management and skin support for your pets.

Atopy Relief

Atopy Relief uses a combination of herbs that in western herbal medicine have been known to provide relief of allergy symptoms, reduce inflammation, redness and symptoms of itchy skin, while also supporting the immune system.

SB

S. boulardii is a probiotic strain and yeast that is beneficial in managing gastrointestinal (GI) issues and diarrhoea. But it also shows promise in helping with other conditions, such as heart functions and parasite infections. It is able to be taken while an animal is on antibiotics and research shows it can reduce the duration of time antibiotics are required.

Saccharomyces Boulardii is a gut-friendly yeast probiotic that is safe for dogs and cats. As a probiotic, it brings health benefits to the GI system and ultimately, the immune system.

Allergen Free

LUCAA+ Pet Probiotic Allergen-Free (previously called Allergy-Free) is a dog skin allergy prevention spray. You can use it to significantly improve uncomfortable, itchy skin (atopic) symptoms caused by environmental and seasonal allergies. The spray is easy to use for pets with itchy, flaky skin, excessive scratching, hot spots and rashes. It helps your pet to feel happier and more comfortable. Suitable for cats and other pets too!

Ingredients Plus

PEA

Ultra-micronised Palmitoylethanolamide (P.E.A) in a cellulose capsule. 

Atopy Relief

Skullcap (Scutellaria), Nettle Leaf (Urtica dioica),Burdock (Arctium lappa), Deglycyrrhizinated Licorice (Glycyrrhiza glabra),Astragalus (Astragalus membranaceus), Water(H2O), Ethanol (C2H6O)

SB

Allergen Free

Water >30%
Anionic surfactants <5%
Biological agents – microorganisms EU Group 1
Natural scent of Aloe Vera <1%

Directions & Storage Plus

Store below 25 degrees Celsius. Keep in a cool dry place out of direct sunlight. Keep container tightly closed.

Keep out of reach of children.

Suitable for dogs and cats.

Cautions Plus

Discontinue 7 days prior to general anaesthesia or procedure when a sedative may be administered.

Do not give during pregnancy and lactation without professional veterinary supervision.

The Science Plus

Lin, C. C., & Shieh, D. E. (1996). The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin. The American journal of Chinese medicine, 24(01), 31-36.

Mittman, P. (1990). Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis. Planta medica, 56(01), 44-47.

Nagle, T. M., Torres, S. M., Horne, K. L., Grover, R., & Stevens, M. T. (2001). A randomized, double‐blind, placebo‐controlled trial to investigate the efficacy and safety of a Chinese herbal product (P07P) for the treatment of canine atopic dermatitis. Veterinary Dermatology, 12(5), 265-274.

Tamaya, T., Sato, S., & Okada, H. H. (1986). Possible mechanism of steroid action of the plant herb extracts glycyrrhizin, glycyrrhetinic acid, and paeoniflorin: inhibition by plant herb extracts of steroid protein binding in the rabbit. American journal of obstetrics and gynecology, 155(5), 1134-1139.

D'Angelo S, Fracassi F, Bresciani F, Galuppi R, Diana A, Linta N, Bettini G, Morini M, Pietra M. Effect of Saccharomyces boulardii in dog with chronic enteropathies: double-blinded, placebo-controlled study. Vet Rec. 2018 Mar 3;182(9):258. doi: 10.1136/vr.104241. Epub 2017 Dec 6. PMID: 29212912.

Garrigues Q, Mugnier A, Chastant S, Sicard F, Martin JC, Svilar L, Castex M, Ramis-Vidal MG, Rovere N, Michaud L, David P, Mansalier E, Rodiles A, Mila H, Apper E. The supplementation of female dogs with live yeast Saccharomyces cerevisiae var. boulardii CNCM I-1079 acts as gut stabilizer at whelping and modulates immunometabolic phenotype of the puppies. Front Nutr. 2024 Apr 12;11:1366256. doi: 10.3389/fnut.2024.1366256. PMID: 38680531; PMCID: PMC11048480.

Meineri G, Martello E, Atuahene D, Miretti S, Stefanon B, Sandri M, Biasato I, Corvaglia MR, Ferrocino I, Cocolin LS. Effects of Saccharomyces boulardii Supplementation on Nutritional Status, Fecal Parameters, Microbiota, and Mycobiota in Breeding Adult Dogs. Vet Sci. 2022 Jul 28;9(8):389. doi: 10.3390/vetsci9080389. PMID: 36006304; PMCID: PMC9414249.

Pais P, Almeida V, Yılmaz M, Teixeira MC. Saccharomyces boulardii: What Makes It Tick as Successful Probiotic? J Fungi (Basel). 2020 Jun 4;6(2):78. doi: 10.3390/jof6020078. PMID: 32512834; PMCID: PMC7344949.

Whittemore JC, Moyers TD, Price JM. Randomized, controlled, crossover trial of prevention of antibiotic-induced gastrointestinal signs using a synbiotic mixture in healthy research dogs. J Vet Intern Med. 2019 Jul;33(4):1619-1626. doi: 10.1111/jvim.15553. Epub 2019 Jul 3. PMID: 31268578; PMCID: PMC6639531.

Abramo, F., Campora, L., Albanese, F., della Valle, M. F., Cristino, L., Petrosino, S., ... & Miragliotta, V. (2014). Increased levels of palmitoylethanolamide and other bioactive lipid mediators and enhanced local mast cell proliferation in canine atopic dermatitis. BMC Veterinary Research, 10, 1-10.

Cerrato, S., Brazis, P., Della Valle, M. F., Miolo, A., Petrosino, S., Di Marzo, V., & Puigdemont, A. (2012). Effects of palmitoylethanolamide on the cutaneous allergic inflammatory response in Ascaris hypersensitive Beagle dogs. The Veterinary Journal, 191(3), 377-382.

della Rocca, G.; Re, G. Palmitoylethanolamide and Related ALIAmides for Small Animal Health: State of the Art. Biomolecules 2022, 12, 1186. https://doi.org/10.3390/biom12091186

della Rocca G, Gamba D. Chronic Pain in Dogs and Cats: Is There Place for Dietary Intervention with Micro-Palmitoylethanolamide? Animals. 2021; 11(4):952. https://doi.org/10.3390/ani11040952

Gugliandolo E, Peritore AF, Piras C, Cuzzocrea S, Crupi R. Palmitoylethanolamide and Related ALIAmides: Prohomeostatic Lipid Compounds for Animal Health and Wellbeing. Veterinary Sciences. 2020; 7(2):78. https://doi.org/10.3390/vetsci7020078

Noli, C., Della Valle, M. F., Miolo, A., Medori, C., Schievano, C., & Skinalia Clinical Research Group. (2015). Efficacy of ultra‐micronized palmitoylethanolamide in canine atopic dermatitis: an open‐label multi‐centre study. Veterinary dermatology, 26(6), 432-e101.

Petrosino, S., Schiano Moriello, A., Cerrato, S., Fusco, M., Puigdemont, A., De Petrocellis, L., & Di Marzo, V. (2016). The anti‐inflammatory mediator palmitoylethanolamide enhances the levels of 2‐arachidonoyl‐glycerol and potentiates its actions at TRPV1 cation channels. British Journal of Pharmacology, 173(7), 1154-1162.

Re, G., Barbero, R., Miolo, A., & Di Marzo, V. (2007). Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals. The Veterinary Journal, 173(1), 21-30.

Scuderi C, Golini L. Successful and Unsuccessful Brain Aging in Pets: Pathophysiological Mechanisms behind Clinical Signs and Potential Benefits from Palmitoylethanolamide Nutritional Intervention. Animals. 2021; 11(9):2584. https://doi.org/10.3390/ani11092584

 

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