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$192.50
PEA (Palmitoylethanolamide) (Size)
300mg
600mg
1000mg
PEA (Palmitoylethanolamide) (Size)
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Features Plus

The Senior Pet Bundle is designed to reduce cognitive decline, promote enhanced brain activity in dogs and cats, while also providing natural pain relief and relief of arthritic symptoms.

✔ May reduce neurodegeneration and neuronal cell death
✔ May support the survival of neuronal cells by stimulating nerve growth factor
✔ May enhance myelination
✔ Promotes a more resilient immune system
✔ Supports healthy ageing
✔ Aids in joint injury prevention

✔ Improve joint health and mobility
✔ Support joint and nerve pain
✔ Relieve arthritic symptoms
✔ Reduce inflammation
✔ Support gut and skin health

Ingredients Plus

Lion's Mane

Each 1mL contains:

500mg of dried fruiting body equivalent Lion’s Mane (Hericium erinaceus)

Arthritis Care

Boswellia Serrata (Boswellia), Zingiber officinale (Ginger), Apium graveolens (Celery Seed), Salix Alba (White Willow Bark), Glucosamine Hydrochloride, Chondroitin, Rosa canina L. (Rosehips), Menyanthes (Bog Bean), Achillea millefolium (Yarrow), Taraxacum officinale (Dandelion Root)

PEA

Ultra-micronised Palmitoylethanolamide (P.E.A) in a cellulose capsule. 

Directions & Storage Plus

Store below 25 degrees Celsius. Keep in a cool dry place out of direct sunlight. Keep container tightly closed. Keep out of reach of children.

Cautions Plus

Discontinue 7 days prior to general anaesthesia or procedure when a sedative may be administered.

Do not give during pregnancy and lactation without professional veterinary supervision.

The Science Plus

Cho HW, Choi S, Seo K, Kim KH, Jeon JH, Kim CH, Lim S, Jeong S, Chun JL. Gut microbiota profiling in aged dogs after feeding pet food contained Hericium erinaceus. J Anim Sci Technol. 2022 Sep;64(5):937-949. doi: 10.5187/jast.2022.e66. Epub 2022 Sep 30. PMID: 36287790; PMCID: PMC9574611

Xiao, J. H., Xiao, D. M., Chen, D. X., Xiao, Y., Liang, Z. Q., & Zhong, J. J. (2012). Polysaccharides from the Medicinal Mushroom Cordyceps taii Show Antioxidant and Immunoenhancing Activities in a D‐Galactose‐Induced Aging Mouse Model. Evidence‐based Complementary and Alternative Medicine, 2012(1), 273435.

Andreani, G., Ferlizza, E., Macrì, E., Beghelli, D., & Isani, G. (2017). Effect of Boswellia serrata supplementation in addition to insulin on glycemic control in a diabetic dog. SLOVENIAN VETERINARY RESEARCH, 54(4), 173-179.

Caterino, C., Aragosa, F., Della Valle, G., Costanza, D., Lamagna, F., Piscitelli, A., ... & Fatone, G. (2021). Clinical efficacy of Curcuvet and Boswellic acid combined with conventional nutraceutical product: An aid to canine osteoarthritis. PLoS One, 16(5), e0252279.

Elisa, M., Mauro, B., Raffaella, A., Elena, B., Franco, D., Daniela, P., & Natascia, B. (2018). Evaluation of the efficacy of a dietary supplement in alleviating symptoms in dogs with osteoarthritis. JOURNAL OF FOOD AND NUTRITION, 4, 1-8.

Gabriele, V., Bisanzio, D., Riva, A., Meineri, G., Adami, R., & Martello, E. (2023). Long-term effects of a diet supplement containing Cannabis sativa oil and Boswellia serrata in dogs with osteoarthritis following physiotherapy treatments: a randomised, placebo-controlled and double-blind clinical trial. Natural Product Research, 37(11), 1782-1786.

Martello, E., Bigliati, M., Adami, R., Biasibetti, E., Bisanzio, D., Meineri, G., & Bruni, N. (2022). Efficacy of a dietary supplement in dogs with osteoarthritis: A randomized placebo-controlled, double-blind clinical trial. PLoS One, 17(2), e0263971.

Marstrand, K., & Campbell-Tofte, J. (2016). The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies. Botanics: Targets and Therapy, 6, 59–73. https://doi.org/10.2147/BTAT.S55573

Minami, S., Hata, M., Tamai, Y., Hashida, M., Takayama, T., Yamamoto, S., ... & Okamoto, Y. (2011). Clinical application of D-glucosamine and scale collagen peptide on canine and feline orthopedic diseases and spondylitis deformans. Carbohydrate polymers, 84(2), 831-834.

Musco, N., Vassalotti, G., Mastellone, V., Cortese, L., Della Rocca, G., Molinari, M. L., ... & Lombardi, P. (2019). Effects of a nutritional supplement in dogs affected by osteoarthritis. Veterinary medicine and science, 5(3), 325-335.

Neil, K. M., Caron, J. P., & Orth, M. W. (2005). The role of glucosamine and chondroitin sulfate in treatment for and prevention of osteoarthritis in animals. Journal of the American Veterinary Medical Association, 226(7), 1079-1088.

Reichling, J., Schmökel, H., Fitzi, J., Bucher, S., & Saller, R. (2004). Dietary support with Boswellia resin in canine inflammatory joint and spinal disease. Schweizer Archiv für Tierheilkunde, 146(2), 71-79.

Shakibaei, M., Allaway, D., Nebrich, S., & Mobasheri, A. (2012). Botanical extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) suppress IL‐1β‐induced NF‐κB activation in canine articular chondrocytes. Evidence‐Based Complementary and Alternative Medicine, 2012(1), 509383.

Wenz, W., Hornung, C., Cramer, C., Schroeder, M., & Hoffmann, M. (2017). Effect of glucosamine sulfate on osteoarthritis in the cruciate-deficient canine model of osteoarthritis. Cartilage, 8(2), 173-179.

Abramo, F., Campora, L., Albanese, F., della Valle, M. F., Cristino, L., Petrosino, S., ... & Miragliotta, V. (2014). Increased levels of palmitoylethanolamide and other bioactive lipid mediators and enhanced local mast cell proliferation in canine atopic dermatitis. BMC Veterinary Research, 10, 1-10.

Cerrato, S., Brazis, P., Della Valle, M. F., Miolo, A., Petrosino, S., Di Marzo, V., & Puigdemont, A. (2012). Effects of palmitoylethanolamide on the cutaneous allergic inflammatory response in Ascaris hypersensitive Beagle dogs. The Veterinary Journal, 191(3), 377-382.

della Rocca, G.; Re, G. Palmitoylethanolamide and Related ALIAmides for Small Animal Health: State of the Art. Biomolecules 2022, 12, 1186. https://doi.org/10.3390/biom12091186

della Rocca G, Gamba D. Chronic Pain in Dogs and Cats: Is There Place for Dietary Intervention with Micro-Palmitoylethanolamide? Animals. 2021; 11(4):952. https://doi.org/10.3390/ani11040952

Gugliandolo E, Peritore AF, Piras C, Cuzzocrea S, Crupi R. Palmitoylethanolamide and Related ALIAmides: Prohomeostatic Lipid Compounds for Animal Health and Wellbeing. Veterinary Sciences. 2020; 7(2):78. https://doi.org/10.3390/vetsci7020078

Noli, C., Della Valle, M. F., Miolo, A., Medori, C., Schievano, C., & Skinalia Clinical Research Group. (2015). Efficacy of ultra‐micronized palmitoylethanolamide in canine atopic dermatitis: an open‐label multi‐centre study. Veterinary dermatology, 26(6), 432-e101.

Petrosino, S., Schiano Moriello, A., Cerrato, S., Fusco, M., Puigdemont, A., De Petrocellis, L., & Di Marzo, V. (2016). The anti‐inflammatory mediator palmitoylethanolamide enhances the levels of 2‐arachidonoyl‐glycerol and potentiates its actions at TRPV1 cation channels. British Journal of Pharmacology, 173(7), 1154-1162.

Re, G., Barbero, R., Miolo, A., & Di Marzo, V. (2007). Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals. The Veterinary Journal, 173(1), 21-30.

Scuderi C, Golini L. Successful and Unsuccessful Brain Aging in Pets: Pathophysiological Mechanisms behind Clinical Signs and Potential Benefits from Palmitoylethanolamide Nutritional Intervention. Animals. 2021; 11(9):2584. https://doi.org/10.3390/ani11092584

 

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